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Tuesday, 12/8/15
8:00 am - 7:00 pm Registration - Bridge Hall
   
12:00 pm - 1:45 pm

CAREER DEVELOPMENT FORUM: A Networking Session for Young Investigators – Room 214

Networking and career development opportunities for early career scientists.   The session is open to early-career scientists, defined as graduate students, postdoctoral or clinical fellows, or medical students and residents, who are registered attendees of the 2015 SABCS. 

Space in the workshop is limited to 220 participants; registrations will be accepted on a first-come, first-served basis and is free of charge.  You can register for this session when you register for the Symposium.

   
12:00 pm - 1:45 pm SPECIAL SESSION - Advancing Your Career With Advocates - Room 103B
Round table discussions with advocates and investigators (and funders) sharing best practices and successful collaborations in research and clinical settings.
   
12:30 pm - 1:45 pm

SPECIAL SESSION - Breast Cancer Management in Low and Middle Income Countries - Hall D

Moderator: Benjamin O. Anderson, MD
University of Washington
Seattle, WA

Breast cancer early detection strategies in absence of screening mammography
Indraneel Mittra, MBBS, FRCS, PhD
Tata Memorial Centre
Mumbai, INDIA 

Guidelines and management of advanced breast cancer in limited resource settings
Nagi S. El Saghir, MD, FACP
American University of Beirut
Beirut, LEBANON

Breast cancer care delivery in limited resource settings - making systems work
Raul Murillo, MD, MPH
International Agency for Research on Cancer
Lyon, FRANCE

   
2:00 pm - 7:00 pm

EDUCATIONAL SESSIONS - Ballrooms A & B and Hall D

Supported in part by an educational grant from Susan G. Komen®

Updates on advances in key areas and in technologies available for translational research. Many of the sessions will provide attendees with a better understanding of the background leading up to talks they will hear in the succeeding days, and some of the techniques that will be used. The presentations should also provide researchers with ideas and techniques to be considered for their own studies.


2:00 pm - 3:30 pm

Genetic Risk Prediction: Beyond BRCA 1/2 – Ballroom A
Moderator: Virginia G. Kaklamani, MD, DSc
UT Health Science Center
San Antonio, TX

Management of non-BRCA breast cancer predisposition
Mark E. Robson, MD
Memorial Sloan-Kettering Cancer Center
New York, NY

Variants of uncertain significance
Fergus J. Couch, PhD
Mayo Clinic
Rochester, MN                                   

Interpretation of genetic tests and management of patients
Susan M. Domchek, MD
University of Pennsylvania
Philadelphia, PA

Integration of Metabolism and Tumor Biology - Ballroom B
Moderator: Pothana Saikumar, PhD
UT Health Science Center
San Antonio, TX

Role of mitochondrial tumor suppressor genes and metabolism in breast cancer
David R. Gius, MD, PhD
Northwestern University Feinberg School of Medicine
Chicago, IL

A metabolic profile of triple negative breast cancer
Arun Sreekumar, PhD
Baylor College of Medicine
Houston, TX

Metabolic asymmetry in breast cancer: Implications for personalised medicine
Michael Lisanti, MD-PhD
University of Manchester
Manchester, UNITED KINGDOM

Challenges and Complications of Local Therapy – Hall D
Moderator: John R. Benson, MA DM, MD, FRCS
Cambridge University Hospitals NHS Foundation Trust
Cambridge, UNITED KINGDOM

Surveillance of the breast after conservation surgery
Fiona J. Gilbert, MB ChB
University of Cambridge 
Cambridge, UNITED KINGDOM

Indications for nipple sparing mastectomy
Jean-Yves Petit
Istituto Europeo di Oncologia
Milan, ITALY

Post-mastectomy breast reconstruction: defining the effects of adjuvant treatment modalities on surgical outcomes
Hani Sbitany, MD
University of California
San Francisco, CA


3:45 pm - 5:15 pm

Management of Advanced Breast Cancer (ABC) – Ballroom A
Moderator: Fatima Cardoso, MD
Champalimaud Clinical Center
Lisbon, PORTUGAL

Introduction and ABC International Consensus Guidelines
Fatima Cardoso, MD
Champalimaud Clinical Center
Lisbon, PORTUGAL

Longitudinal strategies in ER+ disease
Maura N. Dickler, MD
Memorial Sloan-Kettering Cancer Center
New York, NY

Tailoring chemotherapy
Alistair Ring, MD, FRCP
The Royal Marsden
Sutton, UNITED KINGDOM

Regimens in HER2+ disease
Sara A. Hurvitz, MD
University of California
Los Angeles, CA

Development and Use of Molecular Biomarkers for Cancer – Ballroom B
Moderator: Ben Ho Park, MD, PhD
Johns Hopkins University
Baltimore, MD

Predictive gene expression profiles in breast cancer, where are we?
Daniel F. Hayes, MD, FASCO
University of Michigan Comprehensive Cancer Center
Ann Arbor, MI

Circulating tumor DNA analysis for liquid biopsies: Current status and future opportunities
Maximilian Diehn, MD, PhD
Stanford University School of Medicine
Stanford, CA

Development of molecular and genomic biomarkers: A regulatory path forward
Julia A. Beaver, MD
US Food and Drug Administration
Silver Spring, CA

Less is More: Minimizing Interventions – Hall D
Moderator: Lisa A. Carey, MD
University of North Carolina
Chapel Hill, NC

Less is more: Minimising surgery
Fiona MacNeill, MD, FRCS
The Royal Marsden NHS Foundation Trust
London, UNITED KINGDOM

Tailoring or omitting radiotherapy in early breast cancer
Timothy J. Whelan, BSc, BM, BCh, MSc, FRCPC
Juravinski Cancer Centre
Hamilton, CANADA

Less is more: De-escalating systemic therapy for breast cancer
Hope S. Rugo, MD
University of California
San Francisco, CA


5:30 pm - 7:00 pm

Endocrine Therapy: Optimal Approaches for Pre and Postmenopausal Breast Cancer - Ballroom A
Moderator: Matthew P. Goetz, MD
Mayo Clinic
Rochester, MN

Neoadjuvant endocrine therapy
Cynthia X. Ma, MD, PhD
Washington University
St. Louis, MO

Adjuvant hormonal therapy for premenopausal breast cancer: Considerations for ovarian function suppression and aromatase inhibitors
Matthew P. Goetz, MD
Mayo Clinic
Rochester, MN

Adjuvant endocrine therapy: Is the price of forever too high?
Polly Niravath, MD
Baylor College of Medicine
Houston, TX

Controversies in the Management of DCIS – Ballroom B
Moderator: Seema A. Khan, MD
Northwestern Medical Group
Chicago, IL

Biology of DCIS
Yi Li, PhD
Baylor College of Medicine
Houston, TX

Prognostic indicators in treatment of DCIS
David M. Euhus, MD
Johns Hopkins University
Baltimore, MD

Endocrine management of premalignant lesions and DCIS
E. Shelley Hwang, MD, MPH
Duke University School of Medicine
Durham, NC

Metabolic Syndrome and Obesity in Breast Cancer - Hall D
Moderator: Carlos L. Arteaga, MD
Vanderbilt-Ingram Cancer Center
Vanderbilt University
Nashville, TN

Role for IGF/Insulin signaling in breast cancer
Douglas Yee, MD
University of Minnesota
Minneapolis, MN

Role of adipokines and inflammation in breast cancer risk and progression
Christos Mantzoros, MD, DSc PhD hc mult
Beth Israel Deaconess Medical Center
Boston, MA

Targeted interventions: Metformin and lifestyle change
Pamela J. Goodwin, MD, MSc
Mount Sinai Hospital
Toronto, CANADA               


 7:30 pm - 10:00 pm OPEN SATELLITE EVENT presented by Physicians' Education Resource, LLC (PER) - Marriott Rivercenter, Grand Ballroom (3rd Floor)

Working Group to Advance the Treatment of Triple-Negative Breast Cancer: Examining the Evidence and Looking to the Future
   

Wednesday, 12/9/15
7:00 am - 5:15 pm

Registration - Bridge Hall

   
7:00 am - 8:00 am Continental Breakfast - Exhibit Hall C
   
8:00 am - 8:15 am

Opening Remarks - Hall D

   
8:15 am - 8:45 am

PLENARY LECTURE 1- Hall D

Critical Decision Making in Radiation Therapy for Breast Cancer in 2015
Jay R. Harris, MD
Dana-Farber Cancer Institute
Boston, MA

8:45 am - 11:15 am

GENERAL SESSION 1 - Hall D

   
11:00 am - 5:00 pm EXHIBITS - Exhibit Hall C
   
11:15 am - 12:00 pm

WILLIAM L. MCGUIRE MEMORIAL LECTURE Hall D

The Contribution of NSABP Clinical Trials to the Management of Early Breast Cancer
Norman Wolmark, MD
Allegheny General Hospital
Pittsburgh, PA

   
12:00 pm - 1:00 pm

LUNCH

   
1:00 pm - 2:00 pm

CLINICAL SCIENCE FORUM - Axillary Management in Primary Breast Cancer - Ballroom A

Moderator: Ismail Jatoi, MD, PhD, FACS
UT Health Science Center
San Antonio, TX

Optimal management of the axilla: A look at the evidence
Eleftherios (Terry) P. Mamounas, MD, MPH, FACS
UF Health Cancer Center-Orlando Health
Orlando, FL

Contemporary role of radiotherapy in axillary management
Reshma Jagsi, MD, DPhil
University of Michigan Health System
Ann Arbor, MI

   
1:00 pm - 2:00 pm

BASIC SCIENCE FORUM - Proteomic Analysis of Breast Cancer: Biological and Clinical Findings – Ballroom B  Supported by an educational grant from AstraZeneca

Moderator: Rachel Schiff, PhD
Baylor College of Medicine
Houston, TX

Mass spectrometry-based proteomic and proteogenomic analyses of human breast cancer
Michael A. Gillette, MD, PhD

Broad Institute of MIT and Harvard
Cambridge, MA

Functional proteomics characterization of breast cancer
Gordon B. Mills, MD, PhD
UT MD Anderson Cancer Center
Houston, TX

   
2:15 pm - 3:15 pm

SUSAN G. KOMEN® BRINKER AWARDS FOR SCIENTIFIC DISTINCTION LECTURES - Hall D

Hacking the Hormone Code in ER+ Breast Cancer 
Myles A. Brown, MD
Dana-Farber Cancer Institute
Boston, MA

Lessons learned from an expedition exploring the world of HER2 positive breast cancer 
Martine Piccart, MD, PhD
Jules Bordet Institute
Brussels, BELGIUM

   
3:15 pm - 5:00 pm

GENERAL SESSION 2 - Hall D

   
5:00 pm - 7:00 pm POSTER DISCUSSION 1: Risk and Risk Reduction: Density, NSAIDs, Statins - Ballroom A
   
5:00 pm - 7:00 pm

POSTER DISCUSSION 2: Endocrine Therapies - Ballroom B  Supported by an educational grant from AstraZeneca

   
5:00 pm - 7:00 pm

POSTER SESSION 1 & reception - Halls A-B 

   
7:30 pm - 9:30 pm

OPEN SATELLITE EVENT presented by Research To Practice - Marriott Rivercenter, Grand Ballroom (3rd Floor)

Practical Application of Research Advances and Emerging Data in the Management of Breast Cancer

For more information or to register, please visit:
 http://www.researchtopractice.com/Meetings/SA2015


Thursday, 12/10/15
7:00 am - 5:15 pm

Registration - Bridge Hall

   
 7:30 am - 9:00 am POSTER DISCUSSION 3: Novel Targets - Ballroom A
   
7:30 am - 9:00 am

POSTER SESSION 2 & continental breakfast - Halls A-B

   
9:00 am - 9:30 am

PLENARY LECTURE 2 - Hall D

Clonal Dynamics and Breast Cancer Subtypes
Samuel Aparicio, BM, BCh, PhD, FRCPath
The University of British Columbia
Vancouver, CANADA

   
9:30 am - 11:30 am

GENERAL SESSION 3 - Hall D

   
 11:00 am - 5:00 pm  Exhibits
   
11:30 am - 12:00 pm AACR DISTINGUISHED LECTURESHIP IN BREAST CANCER RESEARCH - Hall D

Molecular Evolution Under Neoadjuvant Chemotherapy
Anne-Lise Børresen-Dale, DSc
Oslo University Hospital
Oslo, NORWAY
   
12:00 pm - 1:00 pm Lunch
   
1:00 pm - 2:00 pm

CASE DISCUSSION 1 - Ballroom A

Moderator: Mothaffar Rimawi, MD
Baylor College of Medicine
Houston, TX

   
1:00 pm - 2:00 pm

BASIC SCIENCE FORUM - Ballroom B

Novel and Unconventional Drivers of Breast Tumorigenesis

Moderator: Yi Li, PhD
Baylor College of Medicine
Houston, TX

Insights from a compendium of 560 whole-genome sequenced breast cancers
Serena Nik-Zainal, PhD, MRCP, MB BChir
The Wellcome Trust Sanger Institute
Hinxton, UNITED KINGDOM

Roles of epigenetic regulation in breast cancer development
Michael R. Green, MD, PhD
Howard Hughes Medical Institute
Chevy Chase, MD

   
2:15 pm - 3:15 pm

MINI-SYMPOSIUM 1 - Hall D

Cell Cycle Regulation: CDK Inhibitors
Moderator: George W. Sledge, Jr., MD
Stanford University
Stanford, CA

Introduction
George W. Sledge, Jr., MD
Stanford University
Stanford, CA

Beyond CDK 4/6: Targeting additional cell cycle and transcriptional CDKs in breast cancer
Geoffrey Shapiro, MD, PhD
Dana-Farber Cancer Institute
Boston, MA

Targeting CDK 4/6 in breast cancer
Richard Finn, MD
UCLA Jonsson Comprehensive Cancer Center
Los Angeles, CA

   
3:15 pm - 5:00 pm

GENERAL SESSION 4 - Hall D

   
5:00 pm - 7:00 pm POSTER DISCUSSION 4: Barriers to Care and Quality of Life  - Ballroom B
   
5:00 pm - 7:00 pm POSTER DISCUSSION 5: HER2 - Ballroom A
   
5:00 pm - 7:00 pm

POSTER SESSION 3 & reception - Halls A-B


Friday, 12/11/15
7:00 am - 5:15 pm

Registration - Bridge Hall

   
7:30 am - 9:00 am

POSTER SESSION 4 & continental breakfast - Halls A-B 

   
9:00 am - 9:30 am

PLENARY LECTURE 3 - Hall D

Systemic Therapy of HER2 Positive Breast Cancer
Mothaffar Rimawi, MD
Baylor College of Medicine

Houston, TX

   
9:30 am - 11:30 am

General Session 5 - Hall D

   
11:00 am - 5:00 pm Exhibits - Exhibit Hall C
   
11:30 am- 12:00 pm

AACR OUTSTANDING INVESTIGATOR AWARD FOR BREAST CANCER RESEARCH, funded by Susan G. Komen - Hall D

Breast Tumor Heterogeneity: Act Locally, Think Globally
Mohamed Bentires-Alj, Pharm. PhD
Friedrich Miescher Institute for Biomedical Research (FMI)
Basel, SWITZERLAND

   
12:00 pm - 1:00 pm

Lunch

   
1:00 pm- 2:00 pm

CASE DISCUSSION 2 - Ballroom A

Moderator: Mothaffar Rimawi, MD
Baylor College of Medicine
Houston, TX

   
1:00 pm - 2:00 pm

BASIC SCIENCE FORUM – Ballroom B

Targeting Mitochondrial Dysfunction in Breast Cancer

Moderator: Michael T. Lewis, PhD
Baylor College of Medicine
Houston, TX

Dominance of mitochondria in determining the malignant phenotype
Benny Abraham Kaipparettu, M-Pharm, PhD
Baylor College of Medicine
Houston, TX

Targeting mitochondria with FDA-approved antibiotics may be a new therapeutic strategy to eliminate cancer stem cells
Michael Lisanti, MD-PhD
University of Manchester
Manchester, UNITED KINGDOM

   
2:15 pm - 3:15 pm

MINI-SYMPOSIUM 2 - Hall D

Precision Medicine by Sequencing: Is it Ready for Common Clinical Use?

Moderator: Charles M. Perou, PhD
University of North Carolina
Chapel Hill, NC

Introduction
Charles M. Perou
University of North Carolina
Chapel Hill, NC

Defining the actionable genome
David B. Solit, MD
Memorial Sloan-Kettering Cancer Center
New York, NY

Genomics to personalize therapy of metastatic breast cancers
Fabrice André, MD, PhD
Institut Gustave Roussy
Villejuif, FRANCE

   
3:15 pm - 5:00 pm

General Session 6 - Hall D

   
5:00 pm - 7:00 pm Poster Discussion 6: Translational Genomics - Ballroom B
   
5:00 pm - 7:00 pm

Poster Discussion 7: Clinical Applications of Hereditary Multigene Panels - Ballroom A

   
5:00 pm - 7:00 pm

Poster Session 5 & reception - Halls A-B 

   

Saturday, 12/12/15
7:00 am - 9:00 am

Registration - Bridge Hall

   
7:30 am - 9:00 am Poster Session 6 & continental breakfast - Hall C
   
9:00 am - 11:00 am

The Year in Review - Hall D

Moderator: C. Kent Osborne, MD
Baylor College of Medicine
Houston, TX

Update on Basic Science Discoveries
Myles A. Brown, MD
Dana-Farber Cancer Institute
Boston, MA

Update on Translational Research
Matthew J. Ellis, BSc, MB Bchir, MRCP, PhD
Baylor College of Medicine
Houston, TX

Update on Early Breast Cancer
Ruth M. O'Regan, MD
University of Wisconsin
Madison, WI

Update in Metastatic Disease
Sibylle Loibl, MD, PhD
German Breast Group
Neu-Isenburg, GERMANY

   
11:00 am Adjournment
 
 
12:00 pm - 1:45 pm

Special Session - Breast Cancer Management in Low and Middle Countries - Hall D

Moderator: Benjamin O. Anderson, MD

University of Washington

Seattle, WA

Breast cancer early detection strategies in absence of screening mammography

Indraneel Mittra, MBBS, FRCS, PhD
Tata Memorial Centre
Mumbai, INDIA 

Guidelines and management of advanced breast cancer in limited resource settings

Nagi S. El Saghir, MD, FACP

American University of Beirut

Beirut, LEBANON

Breast cancer care delivery in limited resource settings - making systems

Raul Murillo, MD, MPH

Instituto Nacional de Cancerologia de Colombia

Bogota, COLOMBIA